Stem cells are a type of cell with unlimited or immortal self-renewal capacity, capable of producing at least one type of highly differentiated daughter cell. Stem cells have attracted widespread attention due to their immortality and totipotency. As seed cells, stem cells are crucial for the development and homeostasis of tissues and organs, especially for the reconstruction of aging organs and the repair and regeneration after injuries. Aging has become increasingly evident, which has also brought a series of related aging diseases, affecting the quality of people's lives and causing a huge burden on society. People hope to find an important breakthrough to achieve effective renewal, reversal or reconstruction of aging tissues and organs. Therefore, the importance and necessity of research on aging have become increasingly urgent.

Our center use animal models, including zebrafish, mice, and organoids, to explore new factors and mechanisms regulating the development of neural and hematopoietic stem cells; creating models of neurodegenerative and other aging diseases; and combining biological information and new materials to obtain new methods tf delay and reverse aging.

Research Direction

1. Exploring the molecular mechanisms of stem cell (neural/hematopoietic stem cell) homeostasis and differentiation

2. Molecular mechanism of inflammatory cells (microglia) regulating neurodegenerative disease)

3. New materials for drug delivery

Team

Li Li

Ma Yufei

Representative Research Achievement

Disclosing the conserved Bax-Notch signaling axis in microglia development. The research was published in “Nature Communications” journal. 

Revealing that compromised alanyl tRNA synthase leads to ER stress and regulates neuronal survival and neurogenesis through Nrf2. This study was selected as a research highlight and a cover story article in “Development” journal.

Contact Us

023-65935434