Chongqing Institute of Green and Intelligent Technology , Chinese Academy of
Sciences
Search
Yang Xiaohong received Ph.D. from the College of Pharmacy, Chongqing University in June 2019 and then she has been working at the Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences. Her research focuses on the development of novel anti-resistance drugs based on natural products, application research of engineered exosomes in anti-infectious disease treatment, and development of new technologies for precise exosome detection. She has led multiple research projects, including National Natural Science Foundation of China (NSFC) Youth Program, Chongqing Natural Science Foundation General Program and two enterprise collaborative projects. She has published over 30 SCI-indexed papers in journals such as Angewandte Chemie, Journal of Medicinal Chemistry, and Journal of Controlled Release (first/co-first author: 14 papers).
1. Natural Product-Based Anti-Resistance Drug Development
2. Exosome-based Targeted Drug Delivery
3. Development of Novel Precision Detection Technologies Based on Exosomes
2021 Outstanding Special Research Assistant, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences
1. XH Yang#, ZP Wang#, SC Xiang, DQ Wang, Y Zhao, D Luo, YF Qiu, C Huang, J Guo, YW Dai, SL Zhang*, Y He*. Optimization of the natural product Calothrixin A to discover novel dual Topoisomerase I and II inhibitors with improved anticancer activity[J]. J. Med. Chem, 2022, 65, 8040-8061.
2. XH Yang#, BB Xie#, HB Peng#, GM Shi, J Guo, CH Wang*, Y He*. Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes[J]. J. Control. Release, 2021, 329, 454-467.
3. XH Yang, JS Gao, J Guo, ZM Zhao, SL Zhang*, Y He*. Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative[J]. Life Sci, 2019, 219, 20-30.
4. XH Yang, GM Shi, J Guo, CH Wang*, Y He*. exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus[J]. Int J Nanomed, 2018, 13, 8095-8104.
5. HB Peng, BB Xie, JJ Dai, YW Dai, XF Cen, XH Yang*, Y He*. Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar [5] arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus [J]. Mater. Chem. Front., 2022, 6, 360-367.
6. GM Shi#, XH Yang#, JK Wang, WJ Wei, KC Hu, XY Huang, YF Qiu, Y He*. Isolation of extracellular outer membrane vesicles (OMVs) from Escherichia coli using EVscore47 beads. Molecules, 2024, 29(8), 1831.
7. BB Xie#, XH Yang#, RX Zhang, J Guo, Z Chen, Y He*. Hollow and porous Fe3C-NC nanoballoons nanozymes for cancer cell H2O2 detection. Sensor Actuat B-Chem, 2021, 347, 130597.
8. S Chen#, XH Yang#, Y Zhang, Y Liu, H Lu, Y Qiu, C Wang*. Inhalable porous microspheres loaded with metformin and docosahexaenoic acid suppress tumor metastasis by modulating premetastatic niche[J]. Mol Pharmaceutics, 2021, 18(7), 2622-2633.
9. L Peng#, D Xu#, XH Yang#, JK Tang#, XL Feng*, S-L Zhang*, HL Yan*. Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation[J]. Angewandte Chemie, 2019, 131(1), 222-226 .
10. Q Liu#, XH Yang#, J Ji, S-L Zhang*, Y He*. Novel nannocystin A analogues as anticancer therapeutics: Synthesis, biological evaluations and structureeactivity relationship studies[J]. Eur J Med Chem, 2019, 170, 99-111.