Fang Shaoxi, a senior engineer at Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences. a doctor and senior engineer, is mainly committed to the research and development of the next - generation gene sequencer based on nanopores. Focusing on the sequencing requirements, he conducts research on key technologies such as solid-state nanopore fabrication, single-molecule nano- manipulation, and optical/electrical current detection. 

single molecule detection and nanopore fabrication technology

[1] Yin B H#, Fang S X#, Wu B B#, et al. Directly Characterizing the Capture Radius of Tethered Double-Stranded DNA by Single-Molecule Nanopipette Manipulation. ACS Nano, 2024. 18(41): 27962-27973. 

[2] Fang S X#, Zeng D L#, He S X, et al. Fast Fabrication Nanopores on a PMMA Membrane by a Local High Electric Field Controlled Breakdown. Sensors, 2024. 24 (7):2109. 

[3] Fang S X, Yin B H, Xie W Y, et al. Low-noise and High-speed Trans-impedance Amplifier for Nanopore Sensor. Review of Scientific Instruments, 2023. 94(7): 074704. 

[4] Huang Z C, Zeng X Q, Wang D Q*, Fang S X*. Noise Reduction Method of Nanopore Based on Wavelet and Kalman Filter. Applied Sciences, 2022. 12(19):9517. 

[5] Fang S X, Yin B H, Xie W Y, et al. A Novel Dielectric Breakdown Apparatus for Solid-state Nanopore Fabrication with Transient High Electric Field. Review of Scientific Instruments, 2020. 91(9): 93203. 

[6] Yin B H#, Fang S X#, Zhou D M, et al. Nanopore Fabrication via Transient High Electric Field Controlled Breakdown and Detection of Single RNA Molecules. ACS Applied Bio material, 2020. 3(9): 6368−6375. 

[7] He S X#, Fang S X#, Liu X H, et al. Assessment of physiological responses and growth phases of different microalgae under environmental changes by Raman spectroscopy with chemometrics. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 2018. 204: 287-294.