My main research interest is focusing on nanopore-baed DNA sequencing. My research activities also include micro and nano fabrication and its applications. I have successfully fabricated sub-20 nm nanopore in diameter across 8” wafer with semiconductor processes. I have trapped the dsDNA inside nanopore for few mins with our DNA transistor devices. Study the interaction between ds-DNA with different suface properties inside nanopore. Successfully slow down the average translocation velocity of DNA through nanopore with glycerol solution and feed-back controlled circuit. I have 18 granted and pending US patents. I have coauthored over 30 peer-reviewed journal and conference papers.

Solid-state nanopore, single molecule detection technology

VCANBIO Award for Innovations and Breakthroughs in Life Sciences and Medicine

1. Yan Han，Zhou Daming，Shi Biao，Zhang Ziyin，Tian Haibing，Yu Leyong，Wang Yunjiao，Guan Xiyun，Wang Zuobin， Deqiang Wang*, Slowing down DNA translocation velocity using a LiCl salt gradient and nanofiber mesh, European Biophysics Journal, 48 (3), 261- 266 （2019）.

2. Shixuan He, Wanyi Xie, Ping Zhang, Shaoxi Fang, Zhe Li, Peng Tang, Xia Gao, Jinsong Guo, Chaker Tlili, Deqiang Wang*, Preliminary identification of unicellular algal genus by using combined confocal resonance Raman spectroscopy with PCA and DPLS analysis, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,190(5), 417-422 (2018).

3. Lingguo Xie, Xiaodong Qiu, Lan Luo, Xiong Liu, Zhaoxue Li, Zhiyou Zhang, Jinglei Du, Deqiang Wang*, Quantitative detection of the respective concentrations of chiral compounds with weak measurements, Appl. Phys. Lett. 111(19),191106 (2017).

4. Binquan Luan, Shuo Zhou, Deqiang Wang, Ruhong Zhou, Detecting interactions between nanomaterials and cell membranes by synthetic nanopores, ACS Nano, 11(12) 12615-12623 (2017).

5. Yue Zhao, Cuifeng Ying, Qimeng Huang,Yunsheng Deng,Daming Zhou, DeqiangWang*, Wenqiang Lu*, Hongliang Cui* Fabrication of controllable mesh layers above SiNx micro pores with ZnO nanostructures, Microelectronic Engineering, 169,43-48 (2017).

6. Yunsheng Deng, Qimeng Huang, Yue Zhao, Daming Zhou, Cuifeng Ying, Deqiang Wang*, Precise fabrication of a 5nm graphene nanopore with a helium ion microscope for biomolecule detection, Nanotechnology 28(4), 045302 (2017).

7.  Cuifeng Ying, Yuechuan Zhang,Yanxiao Feng, Daming Zhou, Deqiang Wang*, Yinxiao Xiang, Wenyuan Zhou, Yongsheng Chen, Chunlei Du and Jianguo Tian, 3D nanopore shape control by current-stimulus dielectric breakdown, Appl. Phys. Lett.109,063105 (2016).

8. Yanxiao Feng, Yuechuan Zhang, Cuifeng Ying, Deqiang Wang*, Chunlei Du, Nanopore-based 4th-generation DNA Sequencing Techniques, GPB, 13,4-16 (2015).

9. D.Q. Wang, S. Harrer, B.Q. Luan, A.A Afzali, H. Peng, G.A. Stolovitzky. Regulating the transport of DNA through biofriendly nanochannels in a thin solid membrane, Scientific Reports, 4, 3985, Doi:10.1038/srep03985 (2014).

10.D.Q.Wang, Jingwei Bai, G. Stolovitzky, et al., Fabrication of sub-20nm Nanopore Arrays in membranes with mbedded metal electrodes at wafer scales, Nanoscale, 6,8900-8906, DOI: 10.1039/C3NR06723H (2014).